It all depends on what you like. Most people like the strip but it’s more $$$. I always stay at the El Cortez http://www.ecvegas.com it’s downtown and I just drive to the nicer hotels for their ameneties; bars, food, etc., although the El Cortez has everything, it’s just a small place and a bit limited. But it is clean and comfortable. Check the website, I stayed there on a weeknight for $19 and was upgraded to a suite at no charge.

Like the previous respondent I also like the El Cortez, but it is more suitable to middle aged people. Your best bet is the Flamingo or Harrah’s for a reasonable location and a budget price.

Another alternative if you are young is to book a room at "terrible’s casino" and hang out at Hard Rock.

Try Excalibur e.g. – it is a nice hotel with reasonable prices. In order to get the best room price I recommend to use hotel promotion code offers. You will find the latest promo codes on http://www.vegas-hotels-online.com – hope this helps.

Imperial Palace. It is great priced & in the middle of the strip. Good hotel.

***edit**

How much time are you going to really spend in your room on a weekend stay?? I know I do not stay much in the room & can careless about the TV.

The Excalbur widescreen rooms are good for the money.